| University of Rochester School of Medicine & Dentistry |
| Molecular Toxicology & Environmental Medicine Cluster |
| Ph.D. Program in Toxicology |
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Shanna Swan Professor of Obstetrics and Gynecology, and of Environmental Medicine. Director, Center for Reproductive Epidemiology. B.S., City College of New York M.S., Columbia University Ph.D., University of CaliforniaBerkeley E-Mail: shanna_swan@urmc.rochester.edu |
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Impact of Environmental Exposures on Male and Female Reproductive Health.
I am primarily interested in how environmental agents such as organic solvents, water disinfection byproducts, pesticides, plasticizers and other endocrine disrupting chemicals, affect time to pregnancy and infertility, adverse pregnancy outcomes (spontaneous abortion, low birth weight, growth retardation), semen quality, steroids and gonadotropins, gender-related physical and behavior development. For example, the major goal of a current study is to examine the reproductive and developmental effects of in utero exposure to phthalates in the environment. Another study concerns pesticides in current use. The major goal is to examine biomarkers of exposure in fathers, pregnant women and their offspring in relation to the reproductive health of the family. Recent Publications Go here for a more complete list of articles. Swan SH. Environmental phthalate exposure in relation to reproductive outcomes and other health endpoints in humans. Environ Res. 2008 Oct;108(2):177-184. Review. Sathyanarayana S, Calafat AM, Liu F, Swan SH. Maternal and infant urinary phthalate metabolite concentrations: are they related? Environ Res. 2008 Nov;108(3):413-418. Arbuckle TE, Hauser R, Swan SH, Mao CS, Longnecker MP, Main KM, Whyatt RM, Mendola P, Legrand M, Rovet J, Till C, Wade M, Jarrell J, Matthews S, Van Vliet G, Bornehag CG, Mieusset R. Meeting report: measuring endocrine-sensitive endpoints within the first years of life. Environ Health Perspect. 2008 Jul;116(7):948-951. Sathyanarayana S, Karr CJ, Lozano P, Brown E, Calafat AM, Liu F, Swan SH. Baby care products: possible sources of infant phthalate exposure. Pediatrics. 2008 Feb;121(2):e260-268. Swan SH. Alternative measures of fertility compromise. Fertil Steril. 2008 Feb;89(2 Suppl):e27-29. Review. Buck Louis GM, Gray LE Jr, Marcus M, Ojeda SR, Pescovitz OH, Witchel SF, Sippell W, Abbott DH, Soto A, Tyl RW, Bourguignon JP, Skakkebaek NE, Swan SH, Golub MS, Wabitsch M, Toppari J, Euling SY. Environmental factors and puberty timing: expert panel research needs. Pediatrics. 2008 Feb;121 Suppl 3:S192-207. Stahlhut RW, van Wijngaarden E, Dye TD, Cook S, Swan SH. Concentrations of urinary phthalate metabolites are associated with increased waist circumference and insulin resistance in adult U.S. males. Environ Health Perspect. 2007 Jun;115(6):876-882. Stokes-Riner A, Thurston SW, Brazil C, Guzick D, Liu F, Overstreet JW, Wang C, Sparks A, Redmon JB, Swan SH. One semen sample or 2? Insights from a study of fertile men. J Androl. 2007 Sep-Oct;28(5):638-643. Swan SH, Liu F, Overstreet JW, Brazil C, Skakkebaek NE. Semen quality of fertile US males in relation to their mothers' beef consumption during pregnancy. Hum Reprod. 2007 Jun;22(6):1497-1502 Guzick DS, Swan S. The decline of infertility: apparent or real? Fertil Steril. 2006 Sep;86(3):524-526; discussion 534. Swan SH. 2006. Does our environment affect our fertility? Some examples to help reframe the question. Semin Reprod Med. Jul;24(3):142-146. Marsee K, Woodruff TJ, Axelrad DA, Calafat AM, Swan SH. 2006. Estimated daily phthalate exposures in a population of mothers of male infants exhibiting reduced anogenital distance. Environ Health Perspect. Jun;114(6):805-809.
Swan SH. 2006. Semen quality in fertile US men in relation to geographical area and pesticide exposure. Int J Androl. Feb;29(1):62-68; discussion 105-108. Swan SH. 2006. Prenatal phthalate exposure and anogenital distance in male infants. Environ Health Perspect. Feb;114(2):A88-89. Swan SH, Main KM, Liu F, Stewart SL, Kruse RL, Calafat AM, Mao CS, Redmon JB, Ternand CL, Sullivan S, Teague JL; Study for Future Families Research Team. 2005. Decrease in anogenital distance among male infants with prenatal phthalate exposure. Environ Health Perspect. Aug;113(8):1056-1061. Slama R, Bouyer J, Windham G, Fenster L, Werwatz A, Swan SH. 2005. Influence of paternal age on the risk of spontaneous abortion. Am J Epidemiol. May 1;161(9):816-23. Carlsen E, Swan SH, Petersen JH, Skakkebaek NE. 2005. Longitudinal changes in semen parameters in young Danish men from the Copenhagen area. Hum Reprod. Apr;20(4):942-949. Epub 2005 Jan 7. Brazil C, Swan SH, Tollner CR, Treece C, Drobnis EZ, Wang C, Redmon JB, Overstreet JW; Study for Future Families Research Group. 2004. Quality control of laboratory methods for semen evaluation in a multicenter research study. J Androl. 2004 Jul-Aug;25(4):645-656. Brazil C, Swan SH, Drobnis EZ, Liu F, Wang C, Redmon JB, Overstreet JW; Study for Future Families Research Group. 2004. Standardized methods for semen evaluation in a multicenter research study. J Androl. Jul-Aug;25(4):635-644. Fenster L, Waller K, Windham G, Henneman T, Anderson M, Mendola P, Overstreet JW, Swan SH. 2003. Trihalomethane levels in home tap water and semen quality. Epidemiology. Nov;14(6):650-658. Swan SH, Kruse RL, Liu F, Barr DB, Drobnis EZ, Redmon JB, Wang C, Brazil C, Overstreet JW; Study for Future Families Research Group. 2003. Semen quality in relation to biomarkers of pesticide exposure. Environ Health Perspect. Sep;111(12):1478-1484. Swan SH, Brazil C, Drobnis EZ, Liu F, Kruse RL, Hatch M, Redmon JB, Wang C, Overstreet JW; Study For Future Families Research Group. 2003. Geographic differences in semen quality of fertile U.S. males. Environ Health Perspect. Apr;111(4):414-420. Windham GC, Elkin E, Fenster L, Waller K, Anderson M, Mitchell PR, Lasley B, Swan SH. 2002. Ovarian hormones in premenopausal women: variation by demographic, reproductive and menstrual cycle characteristics. Epidemiology. Nov;13(6):675-684. Return to: Faculty Listed by Research Areas Toxicology Cluster Home Page Department of Environmental Medicine University of Rochester Medical Center Revised June 2 2009 (vgl) |