Ph.D. Program in Toxicology

(Names of current trainees or recent graduates are in bold)

Akbiyik F, Ray DM, Gettings KF, Blumberg N, Francis CW, Phipps RP. Human bone marrow megakaryocytesand platelets express PPARgamma, and PPARgamma agonists blunt platelet release of CD40 ligand andthromboxanes. Blood. 2004 Sep 1;104(5):1361-8.

Akbiyik, F., D. M. Ray, H. Bozkaya, and E. Demirpence. Ligand-and-species dependent activation of PPARa. Cell. Physiol. Biochem. 14:269-276, 2004.

Altuwaijri S, Lee DK, Chuang KH, Ting HJ, Yang Z, Xu Q, Tsai MY, Yeh S, Hanchett LA, Chang HC, ChanC. Androgen receptor regulates expression of skeletal muscle-specific proteins and muscle cell types. Endocrine. 2004 Oct;25(1):27-32.

Arndt TL, Stodgell CJ, Rodier PM. The teratology of autism. Int J Dev Neurosci. 2005 Apr-May;23(2-3):189-99.

Baglole CJ, Reddy SY, Pollock SJ, Feldon SE, Sime PJ, Smith TJ, Phipps RP. Isolation and phenotypic characterization of lung fibroblasts. Methods Mol Med. 2005;117:115-27.

Baglole CJ, Bushinsky SM, Garcia TM, Kode A, Rahman I, Sime PJ, Phipps RP. Differential induction of apoptosis by cigarette smoke extract in primary human lung fibroblast strains: implications for emphysema. Am J Physiol Lung Cell Mol Physiol. 2006 Jan 27; [Epub ahead of print]

Ballatori, N., C.L. Hammond, J.B. Cunningham, S.M. Krance, and R. Marchan. Molecular mechanisms of reduced glutathione transport: Role of the MRP/CFTR/ABCC and OATP/SLC21A families of membrane proteins. Toxicol. Appl. Pharmacol. 204:238-255, 2005.

Ballatori N, and Madejczyk MS. Transport of nonessential metals across mammalian cell membranes. In: Topics in Current Genetics, volume on “Molecular Biology of Metal Homeostasis and Detoxification”,Edited by E. Martinoia, and M.J. Tamas; 14:455-483, 2006.

Ballatori, N., W.V. Christian, J.Y. Lee, P.A. Dawson, C.J. Soroka, J.L. Boyer, M.S. Madejczyk, and N. Li. OSTα-OSTβ, a major basolateral bile acid and steroid transporter in human intestinal, renal, and biliary epithelia. Hepatology, 2005 Dec;42(6):1270-9.

Barlow BK, Lee DW, Cory-Slechta DA, Opanashuk LA. Modulation of antioxidant defense systems by theenvironmental pesticide maneb in dopaminergic cells. Neurotoxicology. 2005 Jan;26(1):63-75.

Bemis JC, Nazarenko DA, and Gasiewicz TA. Coplanar polychlorinated biphenyls activate the aryl hydrocarbon receptor in developing tissues of two TCDD-responsive lacZ mouse lines. Toxicol Sci. 2005 Oct:87(2):529-36.

Bemis JC, and Seegal RF. PCB-induced inhibition of the vesicular monoamine transporter predicts reductions in synaptosomal dopamine content. Toxicol Sci. 2004 Aug:80(2):288-95.

Bonacci TM, Mathews JL, Yuan C, Lehmann DM, Malik S, Wu D, Font JL, Bidlack JM, Smrcka AV. Differential targeting of Gbetagamma-subunit signaling with small molecules. Science. 2006 Apr 21;312(5772):443-6.

Burgess HA, Daugherty LE, Thatcher TH, Lakatos HF, Ray DM, Redonnet M, Phipps RP, Sime PJ. PPARgamma agonists inhibit TGF-beta induced pulmonary myofibroblast differentiation and collagenproduction: implications for therapy of lung fibrosis. Am J Physiol Lung Cell Mol Physiol. 2005 Jun; 288(6): L1146-53

Cory-Slechta DA, Virgolini MB, Thiruchelvam M, Weston DD, Bauter MR. Maternal stress modulates the effects of developmental lead exposure. Environ Health Perspect. 2004 May;112(6):717-30.

Daugherty LE, Maffei FA. Toxicology for the Pediatric Intensivist. In Pediatric Critical Care Review. Jeffrey Rubenstein ed. Springer Verlag. 2006.

Farrer, DG, SM Hueber, and MJ McCabe, Jr. Lead enhances CD4 (+) T cell proliferation indirectly by targeting antigen presenting cells and modulating antigen-specific interactions. Toxicol. Appl.Pharmacol. 2005;207:125-137.

Filbrandt, C., Z. Wu, B. Zlokovic, L. Opanashuk, T. Gasiewicz. Presence and functional activity of the arylhydrocarbon receptor in isolated murine cerebral vascular endothelial cells and astrocytes. Neurotoxicology. 2004 June: 25(4):605-16.

Garrett RW, Gasiewicz TA. The Aryl Hydrocarbon Receptor Agonist 2,3,7,8-Tetrachlorodibenzo-p-dioxin Alters the Circadian Rhythms, Quiescence, and Expression of Clock Genes in Murine HematopoieticStem and Progenitor Cells. Mol Pharmacol. 2006 Mar 23; [Epub ahead of print]

Hammond CL, MS Madejczyk, and N. Ballatori. Activation of plasma membrane reduced glutathionetransport in death receptor apoptosis of HepG2 cells. Toxicol Appl Pharmacol. 2004 Feb 15;195(1):12-22.

Han X, Aguilar-Villalobos M, Allen J, Carlton CS, Robinson R, Bayer C, and Naeher LP. Traffic-related Occupational Exposures to PM2.5, CO, and VOCs in Trujillo, Peru. International Journal of Occupational and Environmental Health. 2005;11:276-288.

Han X, and Naeher LP. A review of traffic-related air pollution exposure assessment studies in the developing world. Environ Int. 2006 Jan;32(1):106-20.

Helt CE, Staversky RJ, Lee YJ, Bambara RA, Keng PC, O'Reilly MA. The Cdk and PCNA domains on p21 Cip1 both function to inhibit G1/S progression during hyperoxia. Am J Physiol Lung Cell Mol Physiol. 2004 Mar;286(3):L506-13.

Helt CE, Cliby WA, Keng PC, Bambara RA, O'Reilly MA. Ataxia telangiectasia mutated (ATM) and ATM and Rad3-related protein exhibit selective target specificities in response to different forms of DNA damage. J. Biol. Chem. 2005 Jan 14;280(2):1186-92.

Henry EC, Bemis JC, Henry O, Kende AS, Gasiewicz TA. A potential endogenous ligand for the aryl hydrocarbon receptor has potent agonist activity in vitro and in vivo. Arch Biochem Biophys. 2006 Mar 3; [Epub ahead of print]

Hong KU, Reynolds SD, Watkins S, Fuchs E, Stripp BR. In vivo differentiation potential of tracheal basal cells:Evidence for multipotent and unipotent subpopulations. Am J Physiol Lung Cell Mol Physiol. 2004 Apr;286(4):L643-9.

Hong KU, Reynolds SD, Watkins S, Fuchs E, Stripp BR. Basal cells are a multipotent progenitor capable ofrenewing the bronchial epithelium. Am J Pathol. 2004 Feb;164(2):577-88.

Hsu CL, Chen YL, Ting HJ, Lin WJ, Yang Z, Zhang Y, Wang L, Wu CT, Chang HC, Yeh S, Pimplikar SW,Chang C. Androgen Receptor (AR) NH2-And COOH-terminal Interactions Result in The Differential Influences on The AR-mediated Transactivation And Cell Growth. Mol Endocrinol. 2005 Feb;19(2):350-61.

Hu YC, Yeh S, Yeh SD, Sampson ER, Huang J, Li P, Hsu CL, Ting HJ, Lin HK, Wang L, Kim E, Ni J, Chang C. Functional domain and motif analyses of androgen receptor coregulator ARA70 and its differential expression in prostate cancer. J Biol Chem. 2004 Aug 6;279(32):33438-46.

Hyuck HL, Cornejo J, Roper JM, Pierce RH, Pryhuber GS. Liver Injury in Tumor Necrosis Factor Alpha Receptor Associated Factor 1 (TRAF 1) Knockout Mice in Response to Intratrachel TNF-Alpha. Am J Respir Crit Care Med, 169:7 A70, 2004.

Lakatos HF, Thatcher TH, Burgess HA, Redonnet MR, Hernady E, Williams JP, Sime PJ. Oropharyngeal aspiration of a silica suspension produces a superior model of silicosis in the mouse when compared to intratracheal instillation. Exp Lung Res 2006, In press.

Lee DW and LA Opanashuk. Polychlorinated Biphenyl Mixture Aroclor 1254-Induced Oxidative Stress Plays a Role in Dopaminergic Cell Injury. Neurotoxicology 25 (2004) 925–939.

Lee DW, Gelein RM, Opanashuk LA. Heme-oxygenase-1 promotes polychlorinated biphenyl mixture aroclor 1254-induced oxidative stress and dopaminergic cell injury. Toxicol Sci. 2006 Mar;90(1):159-67.

Maguire-Zeiss KA, Short DW, Federoff HJ. Synuclein, dopamine and oxidative stress: co-conspirators in Parkinson’s disease? Brain Res Mol Brain Res. 2005 Mar 24:134(1):18-23.

Maniscalco WM, Watkins RH, Roper JM, Staversky R, O'Reilly MA. Hyperoxic Ventilated Premature Baboons Have Increased p53, Oxidant DNA Damage and Decreased VEGF Expression. Pediatr Res. 2005 Sep;58(3):549-56.

Martey CA, Baglole CJ, Gasiewicz TA, Sime PJ, Phipps RP. The aryl hydrocarbon receptor is a regulator of cigarette smoke induction of the cyclooxygenase and prostaglandin pathways in human lung fibroblasts.Am J Physiol Lung Cell Mol Physiol. 2005 Sep;289(3):L391-9.

Martey CA, Pollock SJ, Turner CK, O'Reilly KM, Baglole CJ, Phipps RP, Sime PJ. Cigarette smoke induces cyclooxygenase-2 and microsomal prostaglandin E2 synthase in human lung fibroblasts: implicationsfor lung inflammation and cancer. Am J Physiol Lung Cell Mol Physiol. 2004 Nov;287(5):L981-91.

Mazzatti DJ, Lee YJ, Helt CE, O'Reilly MA, Keng PC. p53 modulates radiation sensitivity independent of p21 transcriptional activation. Am J Clin Oncol. 2005 Feb;28(1):43-50.

McCollum G, Keng PC, States JC, McCabe MJ, Jr. Arsenite Delays Progression through Each Cell Cycle Phase and Induces Apoptosis following G2/M Arrest in U937 Myeloid Leukemia Cells. J Pharmacol Exp Ther. 2005;313:877-87.

Minsavage GD, Park SK, Gasiewicz TA. The aryl hydrocarbon receptor (AhR) tyrosine 9, a residue that isessential for AhR DNA binding activity, is not a phosphoresidue but augments AhR phosphorylation. J Biol Chem. 2004 May 14;279(20):20582-93.

O’Reilly MA, Vitiello PF, Gehen SC, Staversky RJ: P21^{Cip1/WAF1/Sdi1} does not affect expression of base excision DNA repair enzymes during chronic oxidative stress. Antioxid Redox Signal 2005, May-Jun; 7(56):719-25.

Palermo CM, Westlake CA, Gasiewicz TA. Epigallocatechin gallate inhibits aryl hydrocarbon receptor gene transcription through an indirect mechanism involving binding to a 90 kDa heat shock protein.Biochemistry. 2005 Apr 5;44(13):5041-52.

Perry SW, Norman JP, Gelbard HA. Adjunctive therapies for HIV-1 associated neurologic disease. Neurotox Res. 2005;8(1-2):161-6.

Perry SW, Norman JP, Litzburg A, Zhang D, Dewhurst S, Gelbard HA. HIV-1 transactivator of transcriptionprotein induces mitochondrial hyperpolarization and synaptic stress leading to apoptosis. J Immunol. 2005 Apr 1;174(7):4333-44.

Perry SW, Norman JP, Litzburg A, Gelbard HA. Antioxidants are required during the early critical period, butnot later, for neuronal survival. J Neurosci Res. 2004 Nov 15;78(4):485-92.

Phipps RP, EP Ryan and SH Bernstein. Inhibition of cyclooxygenase-2: a new targeted therapy for B cell lymphoma. Leukemia Research. 2004:28:109-111.

Pryhuber GS, Huyck HL, Roper JM, Cornejo J, O'Reilly MA, Pierce RH, Tsitsikov EN. Acute tumor necrosis factor-alpha-induced liver injury in the absence of tumor necrosis factor receptor-associated factor 1 gene expression. Am J Pathol. 2005 Jun;166(6):1637-45.

Ray DM, Akbiyik F, Bernstein SH, Phipps RP. CD40 engagement prevents peroxisome proliferator-activated receptor gamma agonist-induced apoptosis of B lymphocytes and B lymphoma cells by an NF-kappaBdependent mechanism. J Immunol. 2005 Apr 1;174(7):4060-9.

Ray DM, Bernstein SH, Phipps RP. Human multiple myeloma cells express peroxisome proliferator-activated receptor gamma and undergo apoptosis upon exposure to PPARgamma ligands. Clin Immunol. 2004 Nov;113(2):203-13.

Ray, D. M., K. M. Morse, S. P. Hilchey, T. M. Garcia, R. E. Felgar, S. B. Maggirwar, R. P. Phipps, and S. H.Bernstein. 2006. The novel Triterpenoid 2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid (CDDO) induces apoptosis of human diffuse large B cell lymphoma cells through a Peroxisome Proliferator-Activated Receptor g independent pathway. Exp Hematology. In press, 2006.

Reeves R, Thiruchelvam M, Richfield EK, Cory-Slechta DA. The effect of developmental exposure to the fungicide triadimefon on behavioral sensitization to triadimefon during adulthood. Toxicol Appl Pharmacol. 2004 Oct 1; 200(1):54-63.

Reeves R, Thiruchelvam M, Cory-Slechta DA. Expression of behavioral sensitization to the cocaine-like fungicide triadimefon is blocked by pretreatment with AMPA, NMDA and DA D1 receptor antagonists.Brain Res. 2004 May 22; 1008(2):155-67.

Reeves R, Thiruchelvam M, Cory-Slechta DA. Development of behavioral sensitization to the cocaine-like fungicide triadimefon is prevented by AMPA, NMDa, DA D1 but not DA D2 receptor antagonists.Toxicol Sci. 2004 May; 79(1):123-36. Epub 2004 Mar 10.

Reynolds SD, Giangreco A, Hong KU, McGrath KE, Ortiz LA, Stripp BR. Airway injury in lung disease pathophysiology: selective depletion of airway stem and progenitor cell pools potentiates lung inflammation and alveolar dysfunction. Am J Physiol Lung Cell Mol Physiol. 2004 Dec; 287(6):L1256-65.

Roper JM, Mazzatti Dj, Watkins RH, Maniscalco WM, Keng PC, and O’Reilly MA. In vivo exposure to hyperoxia induces DNA damage in a population of alveolar type II epithelial cells. Am J Physiol Lung Cell Mol Physiol. 286: l1045-1054, 2004.

Roper JM, Gehen SC, Staversky RJ, Hollander MC, Fornace AJ Jr, O'Reilly MA. Loss of Gadd45a does not modify the pulmonary response to oxidative stress. Am J Physiol Lung Cell Mol Physiol. 2005 Apr;288(4):L663-71.

Ryan EP, SJ Pollock, TI Murant, SH Bernstein, and RP Phipps. Activated human B lymphocytes express cyclooxygenase-2 and cyclooxygenase inhibitors attenuate antibody production. Journal of Immunology. 2005:174:2619-2626.

Ryan EP, Pollock SJ, Kaur K, Felgar RE, Bernstein SH, Chiorrazi N, Phipps RP. Constitutive and activation-inducible cyclooxygenase-2 expression enhances survival of chronic lymphocytic leukemia B cells. Clin Immunol. 2006 Feb 9; [Epub ahead of print]

Singal M, Finkelstein JN. Use of indicator cell lines for determining inflammatory gene changes and screeningthe inflammatory potential of particulate and non-particulate stimuli. Inhal Toxicol. 2005 Aug;17(9):415-25.

Singal M, Finkelstein JN. Amorphous silica particles promote inflammatory gene expression through the redoxsensitive transcription factor, AP-1, in alveolar epithelial cells. Exp Lung Res. 2005 Jul-Aug;31(6):581-97.

Silva VM, Corson N, Elder A, Oberdorster G. The rat ear vein model for investigating in vivo thrombogenicityof ultrafine particles (UFP). Toxicol Sci. 2005 Jun;85(2):983-9.

Sime PJ, Kottman RM, Lakatos HF, Thatcher TH. The Role of TGF-beta in Radiation and Chemotherapy Induced Pulmonary Fibrosis: Inhibition of TGF-beta as a Novel Therapeutic Strategy. In: Transforming growth factor-beta in cancer therapy; Humana Press. Ed. S. Jakowleu, 2006, In press.

Sowden MP, Lehmann DM, Lin X, Smith CO, Smith HC. Identification of novel alternative splice variants of APOBEC-1 complementation factor with different capacities to support apolipoprotein B mRNA editing. J Biol Chem. 2004 Jan 2;279(1):197-206.

Su C, Gao G, Schneider S, Helt C, Weiss C, O'Reilly MA, Bohmann D, Zhao J. DNA damage inducesdownregulation of histone gene expression through the G(1) checkpoint pathway. EMBO J. 2004 Mar 10; 23(5):1133-43.

Ting HJ, Hu YC, Chang C. Actin monomer enhances supervillin-modulated androgen receptor transactivation. Biochem Biophys Res Commun. 2004 Jun 25; 319(2):393-396.

Virgolini MB, Bauter MR, Weston DD, Cory-Slechta DA. Permanent alterations in stress responsivity infemale offspring subjected to combined maternal lead exposure and/or stress. Neurotoxicology. 2006 Jan;27(1):11-21

Virgolini MB, Chen K, Weston DD, Bauter MR, Cory-Slechta DA. Interactions of chronic lead exposure and intermittent stress: consequences for brain catecholamine systems and associated behaviors and HPA axis function. Toxicol Sci. 2005 Oct;87(2):469-82.

Virgolini MB, Volosin M, Fulginiti AS, Cancela LM. Amphetamine and stress responses in developmentally lead-exposed rats. Neurotoxicol Teratol. 2004 Mar-Apr;26(2):291-303.

Vitiello PF, Staversky RJ, Gehen SC, Johnston CJ, Finkelstein JN, Wright TW, O'reilly MA. p21Cip1 Protection against Hyperoxia Requires Bcl-XL and Is Uncoupled from Its Ability to Suppress Growth. Am J Pathol. 2006 Jun;168(6):1838-47.

Williamson MA, Gasiewicz TA, Opanashuk LA. Aryl Hydrocarbon Receptor Expression and Activity inCerebellar Granule Neuroblasts: Implications for Development and Dioxin Neurotoxicity. Toxicol Sci. 2005 Feb;83(2):340-8.