|University of Rochester |
School of Medicine & Dentistry
|Molecular Toxicology & Environmental Medicine Cluster|
|Ph.D. Program in Toxicology|
| Molecular Mechanisms of Prostate Cancer Progression
Since cloning androgen receptors (AR) (Science, 1988), finding the first AR coactivators (PNAS, 1996) and their linkage in prostate cancer (Lancet, 1997), and generation the first tissue- specific knockout AR mouse via cre-lox system (PNAS, 2002). Our laboratory has continued to focus on the study of molecular mechanisms of steroid hormone function, especially androgen action in prostate, testis, breast and brain. The lab goals are to study the physiological functions of AR in various target organs, to elucidate the mechanisms of how prostate cancer progresses from an androgen-dependant to an androgen-independent stage, and also develop the new antiandrogene without progression into antiandrogen withdrawal syndrome.The following summarizes our current AR research efforts from FIVE different directions:
For the orphan nuclear TR2/TR3/TR4 receptors that our Lab cloned, we
will concentrate on the following topics:
Ma WL, Hsu CL, Wu MH, Wu CT, Wu CC, Lai JJ, Jou YS, Chen CW, Yeh S, Chang C. Androgen Receptor Is a New Potential Therapeutic Target for the Treatment of Hepatocellular Carcinoma. Gastroenterology. 2008 May 22. [Epub ahead of print]
Ting HJ, Chang C. Actin associated proteins function as androgen receptor coregulators: An implication of androgen receptor's roles in skeletal muscle. J Steroid Biochem Mol Biol. 2008 Jun 11. [Epub ahead of print]
Lin HY, Yu IC, Wang RS, Chen YT, Liu NC, Altuwaijri S, Hsu CL, Ma WL, Jokinen J, Sparks JD, Yeh S, Chang C. Increased hepatic steatosis and insulin resistance in mice lacking hepatic androgen receptor. Hepatology. 2008 Jun;47(6):1924-1935.
Chen YT, Collins LL, Chang SS, Chang C. The roles of testicular orphan nuclear receptor 4 (TR4) in cerebellar development. Cerebellum. 2008 Mar 27. [Epub ahead of print]
Li G, Lee YF, Liu S, Cai Y, Xie S, Liu NC, Bao BY, Chen Z, Chang C. Oxidative stress stimulates testicular orphan receptor 4 through forkhead transcription factor forkhead box O3a. Endocrinology. 2008 Jul;149(7):3490-3499
Cai Y, Lee YF, Li G, Liu S, Bao BY, Huang J, Hsu CL, Chang C. A new prostate cancer therapeutic approach: combination of androgen ablation with COX-2 inhibitor. Int J Cancer. 2008 Jul 1;123(1):195-201.
Yu IC, Lin HY, Liu NC, Wang RS, Sparks JD, Yeh S, Chang C. Hyperleptinemia without obesity in male mice lacking androgen receptor in adipose tissue. Endocrinology. 2008 May;149(5):2361-2368.
Chen LM, Wang RS, Lee YF, Liu NC, Chang YJ, Wu CC, Xie S, Hung YC, Chang C. Subfertility with defective folliculogenesis in female mice lacking testicular orphan nuclear receptor 4. Mol Endocrinol. 2008 Apr;22(4):858-867.
Yeh, S., Miyamoto, H., Shima, H. and Chang, C. 1998. From estrogen to androgen receptor: a new pathway for sex hormone in human prostate. Proc. Natl. Acad. Sci. U S A , 95:5527-5532.
Chang, C., Kokontis, J., and Liao, S. 1988. Molecular cloning of human and rat complementary DNA encoding androgen receptors. Science, 240:324-326.
Faculty Listed by Research Areas
Toxicology Cluster Home Page
Department of Environmental Medicine
University of Rochester Medical Center
Revised July 23 2008 (vgl)