|University of Rochester|
School of Medicine & Dentistry
|Molecular Toxicology & Environmental Medicine Cluster|
|Ph.D. Program in Toxicology|
|Deborah A. Cory-Slechta|
Professor of Environmental Medicine
Ph.D. 1977 (University of Minnesota)
Environmental Neurotoxicants as Risk Factors for Behavioral
Disorders and Neurodegenerative Diseases
This laboratory focuses on understanding the contribution of environmental chemical exposures to human diseases and disorders of the nervous system in order to evaluate human health risks and to determine effective strategies for treatment.
Ongoing studies focus on three areas. One involves determination of the neurochemical mechanisms in rodent models by which chronic low level lead (Pb) exposures disrupt complex cognitive/executive functions, including learning and attention. This will allow development of behavioral and/or pharmacological therapeutic strategies for such deficits.
Our studies of behavioral deficits in lead-exposed children facilitate direct translation of findings from experimental models. Related studies are now examining the combined impacts of low level lead exposures and stress in both rat and mouse models, since these are co-occurring risk factors that both target the mesolimbic dopamine system of the brain, and our previous studies show that Pb exposure permanently alters HPA axis function.
Another line of research in this laboratory continues to explore the contribution of pesticide exposures to the etiology of the Parkinsons disease phenotype, particularly when such exposures occur in combination with other risk factors, including developmental period of exposure, aging, genetic background and gender. Future studies aim to examine both the role of pesticides in addition to the paraquat + maneb model as etiological factors and to begin to determine mechanisms and markers that are common across models of the PD phenotype.
Kobrosly RW, van Wijngaarden E, Galea S, Cory-Slechta DA, Love T, Hong C, Shamlaye CF, and Davidson PW. Socioeconomic position and cognitive function in the Seychelles: a life course analysis. Neuroepidemiology. 2011;36(3):162-8. Epub 2011 Apr 20.
van Wijngaarden E, Winters PC, Cory-Slechta DA. Blood lead levels in relation to cognitive function in older U.S. adults. Neurotoxicology. 2011 Jan;32(1):110-5. Epub 2010 Nov 17.
Rossi-George A, Virgolini MB, Weston D, Thiruchelvam M, and Cory-Slechta DA. Interactions of lifetime lead exposure and stress: behavioral, neurochemical and HPA axis effects. Neurotoxicology. 2011 Jan;32(1):83-99. Epub 2010 Sep 25.
Cory-Slechta DA, Stern S, Weston D, Allen JL, and Liu S. Enhanced learning deficits in female rats following lifetime pb exposure combined with prenatal stress. Toxicol Sci. 2010 Oct;117(2):427-38. Epub 2010 Jul 16.
Cory-Slechta DA, Virgolini MB, Rossi-George A, Weston D, Thiruchelvam M. Experimental manipulations blunt time-induced changes in brain monoamine levels and completely reverse stress, but not Pb+/-stress-related modifications to these trajectories. Behav Brain Res. 2009 Dec 14;205(1):76-87.
van Wijngaarden E, Campbell JR, Cory-Slechta DA. Bone lead levels are associated with measures of memory impairment in older adults. Neurotoxicology. 2009 Jul;30(4):572-580.
Bronstein J, Carvey P, Chen H, Cory-Slechta D, DiMonte D, Duda J, English P, Goldman S, Grate S, Hansen J, Hoppin J, Jewell S, Kamel F, Koroshetz W, Langston JW, Logroscino G, Nelson L, Ravina B, Rocca W, Ross GW, Schettler T, Schwarzschild M, Scott B, Seegal R, Singleton A, Steenland K, Tanner CM, Van Den Eeden S, Weisskopf M. Meeting report: consensus statement-Parkinsons disease and the environment: collaborative on health and the environment and Parkinsons Action Network (CHE PAN) conference 26-28 June 2007. Environ Health Perspect. 2009 Jan;117(1):117-121.
Virgolini MB, Rossi-George A, Weston D, Cory-Slechta DA. Influence of low level maternal Pb exposure and prenatal stress on offspring stress challenge responsivity. Neurotoxicology. 2008 Nov;29(6):928-939.
Rossi-George A, Virgolini MB, Weston D, Cory-Slechta DA. Alterations in glucocorticoid negative feedback following maternal Pb, prenatal stress and the combination: a potential biological unifying mechanism for their corresponding disease profiles. Toxicol Appl Pharmacol. 2009 Jan 1;234(1):117-127.
Weiss B, Cory-Slechta D, Gilbert SG, Mergler D, Miller E, Miller C, Newland MC, Rice D, Schettler T. The new tapestry of risk assessment. Neurotoxicology. 2008 Sep;29(5):883-1890
Virgolini MB, Rossi-George A, Lisek R, Weston DD, Thiruchelvam M, Cory-Slechta DA. CNS effects of developmental Pb exposure are enhanced by combined maternal and offspring stress. Neurotoxicology. 2008 Sep;29(5):812-827
Lanphear BP, Hornung RW, Khoury J, Dietrich KN, Cory-Slechta DA, Canfield RL. The conundrum of unmeasured confounding: Comment on: Can some of the detrimental neurodevelopmental effects attributed to lead be due to pesticides? by Brian Gulson. Sci Total Environ. 2008 Jun 25;396(2-3):196-200.
Jusko TA, Henderson CR, Lanphear BP, Cory-Slechta DA, Parsons PJ, Canfield RL. Blood lead concentrations < 10 microg/dL and child intelligence at 6 years of age. Environ Health Perspect. 2008 Feb;116(2):243-248.
Cory-Slechta DA, Virgolini MB, Rossi-George A, Thiruchelvam M, Lisek R, Weston D. Lifetime consequences of combined maternal lead and stress. Basic Clin Pharmacol Toxicol. 2008 Feb;102(2):218-227. Review.
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Revised August 31 2011 (vgl)