|University of Rochester|
School of Medicine & Dentistry
|Molecular Toxicology & Environmental Medicine Cluster|
|Ph.D. Program in Toxicology|
|Steve N. Georas|
Professor of Medicine and of Environmental Medicine
B.S. 1983, and M.D. 1987, Brown University
Director, Division of Pulmonary and Critical Care Medicine
Our laboratory investigates the molecular mechanisms for dysregulated immune responses in
asthma and allergic diseases. The lab consists of a dynamic and collaborative group of
research technicians, post-doctoral fellows and students, and we have a long track record
of mentorship in conducting translational studies bridging both basic and clinical research.
Interested students or post-doctoral fellows are encouraged to apply for open positions.
We are currently studying three related areas using both human cells and mouse models in
an integrated fashion.
Emo J, Meednu N, Chapman TJ, Rezaee F, Balys M, Randall T, Rangasamy T, Georas SN.
Lpa2 is a negative regulator of both dendritic cell activation and murine models of allergic lung inflammation.
J Immunol. 2012 Mar 16. [Epub ahead of print]
Rezaee F, Meednu N, Emo JA, Saatian B, Chapman TJ, Naydenov NG, De Benedetto A, Beck LA, Ivanov AI, Georas SN.
Polyinosinic:polycytidylic acid induces protein kinase D-dependent disassembly of apical junctions and barrier dysfunction in airway epithelial cells.
J Allergy Clin Immunol. 2011 Dec;128(6):1216-1224.e11.
Lin X, Sime PJ, Xu H, Williams MA, LaRussa L, Georas SN, Guo J.
Yin yang 1 is a novel regulator of pulmonary fibrosis.
Am J Respir Crit Care Med. 2011 Jun 15;183(12):1689-1697
Qi Y, Operario DJ, Oberholzer CM, Kobie JJ, Looney RJ, Georas SN, Mosmann TR. Human basophils express amphiregulin in response to T cell-derived IL-3. J Allergy Clin Immunol. 2010 Dec;126(6):1260-1266.
Williams MA, Bauer S, Lu W, Guo J, Walter S, Bushnell TP, Lillehoj EP, Georas SN. Deletion of the mucin-like molecule muc1 enhances dendritic cell activation in response to toll-like receptor ligands. J Innate Immun. 2010 Feb;2(2):123-143.
Georas SN. Lysophosphatidic acid and autotaxin: emerging roles in innate and adaptive immunity. Immunol Res. 2009 Jan 30. [Epub ahead of print]
Pietropaoli A, Georas SN. Resolving lung injury: a new role for Tregs in controlling the innate immune response. J Clin Invest. 2009 Oct;119(10):2891-2894.
Guo J, Lin X, Williams MA, Hamid Q, Georas SN. Yin-Yang 1 regulates effector cytokine gene expression and T(H)2 immune responses. J Allergy Clin Immunol. 2008 Jul;122(1):195-201.
Porter M, Karp M, Killedar S, Bauer SM, Guo J, Williams D, Breysse P, Georas SN, Williams MA. Diesel-enriched particulate matter functionally activates human dendritic cells. Am J Respir Cell Mol Biol. 2007 Dec;37(6):706-719.
Georas SN, Berdyshev E, Hubbard W, Gorshkova IA, Usatyuk PV, Saatian B, Myers AC, Williams MA, Xiao HQ, Liu M, Natarajan V. Lysophosphatidic acid is detectable in human bronchoalveolar lavage fluids at baseline and increased after segmental allergen challenge. Clin Exp Allergy. 2007 Mar;37(3):311-322.
Chen R, Roman J, Guo J, West E, McDyer J, Williams MA, Georas SN. Lysophosphatidic acid modulates the activation of human monocyte-derived dendritic cells. Stem Cells Dev. 2006 Dec;15(6):797-804.
Saatian B, Zhao Y, He D, Georas SN, Watkins T, Spannhake EW, Natarajan V. Transcriptional regulation of lysophosphatidic acid-induced interleukin-8 expression and secretion by p38 MAPK and JNK in human bronchial epithelial cells. Biochem J. 2006 Feb 1;393(Pt 3):657-668.
Georas SN, Guo J, De Fanis U, Casolaro V. T-helper cell type-2 regulation in allergic disease. Eur Respir J. 2005 Dec;26(6):1119-1137. Review.
Rangasamy T, Guo J, Mitzner WA, Roman J, Singh A, Fryer AD, Yamamoto M, Kensler TW, Tuder RM, Georas SN, Biswal S. Disruption of Nrf2 enhances susceptibility to severe airway inflammation and asthma in mice. J Exp Med. 2005 Jul 4;202(1):47-59.
Hansel NN, Hilmer SC, Georas SN, Cope LM, Guo J, Irizarry RA, Diette GB. Oligonucleotide-microarray analysis of peripheral-blood lymphocytes in severe asthma. J Lab Clin Med. 2005 May;145(5):263-274.
Georas SN. Inhaled glucocorticoids, lymphocytes, and dendritic cells in asthma and obstructive lung diseases. Proc Am Thorac Soc. 2004;1(3):215-221. Review.