|University of Rochester|
School of Medicine & Dentistry
|Molecular Toxicology & Environmental Medicine Cluster|
|Ph.D. Program in Toxicology|
Michael A. OReilly|
Associate Professor of Pediatrics,
and Environmental Medicine
B.S. 1984 (SUNY Stony Brook)
Ph.D. 1989 (University of Cincinnati)
Oxidative Lung Injury and Repair
We want to know how alveolar epithelial Type II cells respond to elevated oxygen
(hyperoxia) typically used to treat patients suffering from respiratory distress.
Type II cells produce pulmonary surfactant lipids and proteins that maintain alveolar
homeostasis and immunity against respiratory pathogens. They are also transient
amplifying progenitors for Type I cells that exchange oxidant gases between the
lung and blood.
Project 1. Developmental origins of oxidative lung disease.
Project 2. Activation of pro-survival pathways during oxidant lung injury.
Lew BJ, Collins LL, OReilly MA, Lawrence BP. Activation of the aryl hydrocarbon receptor (AhR) during different critical windows in pregnancy alters mammary epithelial cell proliferation and differentiation. Toxicol Sci. 2009 Jun 5. [Epub ahead of print.]
Vitiello PF, Wu YC, Staversky RJ, OReilly MA. p21(Cip1) protects against oxidative stress by suppressing ER-dependent activation of mitochondrial death pathways. Free Radic Biol Med. 2009 Jan 1;46(1):33-41. [Epub 2008 Oct 7.]
Pryhuber GS, Huyck HL, Bhagwat S, OReilly MA, Finkelstein JN, Gigliotti F, Wright TW. Parenchymal Cell TNF Receptors Contribute to Inflammatory Cell Recruitment and Respiratory Failure in Pneumocystis carinii-Induced Pneumonia. J Immunol. 2008 Jul 15;181(2):1409-1419.
Gehen SC, Staversky RJ, Bambara RA, Keng PC, O Reilly MA. hSMG-1 and ATM sequentially and independently regulate the G(1) checkpoint during oxidative stress. Oncogene. 2008 Mar 10; [Epub ahead of print]
OReilly MA, Marr SH, Yee M, McGrath-Morrow SA, Lawrence BP. Neonatal Hyperoxia Enhances the Inflammatory Response in Adult Mice Infected With Influenza A Virus. Am J Respir Crit Care Med. 2008 Feb 21; [Epub ahead of print]
Yao H, Yang SR, Edirisinghe I, Rajendrasozhan S, Caito S, Adenuga D, OReilly MA, Rahman I. Disruption of p21 Attenuates Lung Inflammation Induced by Cigarette Smoke, LPS and fMLP in Mice. Am J Respir Cell Mol Biol. 2008 Jan 31; [Epub ahead of print]
Vitiello PF, Staversky RJ, Keng PC, OReilly MA. PUMA inactivation protects against oxidative stress through p21/Bcl-XL inhibition of bax death. Free Radic Biol Med. 2008 Feb 1;44(3):367-374. Epub 2007 Oct 10.
Gehen SC, Vitiello PF, Bambara RA, Keng PC, OReilly MA. 2007. Downregulation of PCNA potentiates p21-mediated growth inhibition in response to hyperoxia. Am J Physiol Lung Cell Mol Physiol. Mar;292(3):L716-724
Bijli KM, Minhajuddin M, Fazal F, OReilly MA, Platanias LC, Rahman A. 2007. c-Src interacts with and phosphorylates RelA/p65 to promote thrombin-induced ICAM-1 expression in endothelial cells. Am J Physiol Lung Cell Mol Physiol. Feb;292(2):L396-404
Staversky RJ, Vitiello PF, Gehen SC, Helt CE, Rahman A, Keng PC, OReilly MA. 2006 . p21(Cip1/Waf1/Sdi1) protects against hyperoxia by maintaining expression of Bcl-X(L). Free Radic Biol Med. Aug 15;41(4):601-609.
Yee M, Vitiello PF, Roper JM, Staversky RJ, Wright TW, McGrath-Morrow SA, Maniscalco WM, Finkelstein JN, OReilly MA. 2006. Type II epithelial cells are critical target for hyperoxia-mediated impairment of postnatal lung development. Am J Physiol Lung Cell Mol Physiol. Nov;291(5):L1101-1111
Vitiello PF, Staversky RJ, Gehen SC, Johnston CJ, Finkelstein JN, Wright TW, OReilly MA. 2006. p21Cip1 protection against hyperoxia requires Bcl-XL and is uncoupled from its ability to suppress growth. Am J Pathol. Jun;168(6):1838-1847.
Maniscalco WM, Watkins RH, Roper JM, Staversky R, OReilly MA. 2005. Hyperoxic Ventilated Premature Baboons Have Increased p53, Oxidant DNA Damage and Decreased VEGF Expression. Pediatr Res. Sep;58(3):549-556.
Pryhuber GS, Huyck HL, Roper JM, Cornejo J, OReilly MA, Pierce RH, Tsitsikov EN. 2005. Acute tumor necrosis factor-alpha-induced liver injury in the absence of tumor necrosis factor receptor-associated factor 1 gene expression. Am J Pathol. Jun;166(6):1637-1645.
Chess PR, OReilly MA, Sachs F, Finkelstein JN. 2005. Reactive oxidant and p42/44 MAP kinase signaling is necessary for mechanical strain-induced proliferation in pulmonary epithelial cells. J Appl Physiol. Sep;99(3):1226-
OReilly MA, Vitiello PF, Gehen SC, Staversky RJ. 2005. p21(Cip1/WAF1/Sdi1) does not affect expression of base excision DNA repair enzymes during chronic oxidative stress. Antioxid Redox Signal. May-Jun;7(5-6):719-725.
Roper JM, Gehen SC, Staversky RJ, Hollander MC, Fornace Jr AJ, and OReilly MA. 2005. Loss of Gadd45a does not modify the pulmonary response to oxidative stress. Am J Physiol Lung Cell Mol Physiol. Apr;288(4):L663-671.
OReilly MA. 2005. Redox Activation of p21(Cip1/WAF1/Sdi1): A Multifunctional Regulator of Cell Survival and Death. Antioxid Redox Signal. Jan-Feb;7(1-2):108-118.
Helt CE, Cliby WA, Keng PC, Bambara RA, and OReilly MA. 2005. Ataxia Telangiectasia Mutated (ATM) and ATM and Rad3-related Protein Exhibit Selective Target Specificities in Response to Different Forms of DNA Damage. J Biol Chem. Jan 14;280(2):1186-1192.
Mazzatti DJ, Lee YJ, Helt CE, OReilly MA, Keng PC. 2005. p53 modulates radiation sensitivity independent of p21 transcriptional activation. Am J Clin Oncol. Feb;28(1):43-50.
Faculty Listed by Research Areas
Toxicology Cluster Home Page
Department of Environmental Medicine
University of Rochester Medical Center
Revised July 12 2009 (vgl)