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Ph.D. Program in Toxicology


Publications (2007-June 2009)


Publications (2007-June 2009)
    (Names of trainees are in bold)

  • Adenuga D and Rahman I. Oxidative stress, histone deacetylase and corticosteroid resistance in severe asthma and COPD. Current Respiratory Medicine Reviews, 3: 57-68, 2007.
  • Adenuga D, Yao H, March TH, Seagrave J, Rahman I. Histone deacetylase 2 is phosphorylated, ubiquitinated, and degraded by cigarette smoke. Am J Respir Cell Mol Biol. 40(4):464-73, 2009.
  • Aremu DA, Madejczyk MS, and N. Ballatori. N-acetylcysteine as a potential antidote and biomonitoring agent of methylmercury exposure. Environ. Health Persp. 116:26-31, 2008.
  • Baglole CJ, Maggirwar SB, Gasiewicz TA, Thatcher TH, Phipps RP, Sime PJ. The Aryl Hydrocarbon Receptor Attenuates Tobacco Smoke-induced Cyclooxygenase-2 and Prostaglandin Production in Lung Fibroblasts through Regulation of the NF-{kappa}B Family Member RelB. J Biol Chem. 283(43):28944-57, 2008.
  • Baglole CJ, Sime PJ, Phipps RP. Cigarette smoke-induced expression of heme oxygenase-1 in human lung fibroblasts is regulated by intracellular glutathione. Am J Physiol Lung Cell Mol Physiol. 295(4):L624-36, 2008.
  • Ballatori N, Fang F, Christian WV, Li N, Hammond CL. Ostalpha-Ostbeta is required for bile acid and conjugated steroid disposition in the intestine, kidney, and liver. Am J Physiol Gastrointest Liver Physiol. 295(1):G179-G186, 2008.
  • Ballatori N, Krance SM, Marchan R, Hammond CL. Plasma membrane glutathione transporters and their roles in cell physiology and pathophysiology. Mol Aspects Med. 30(1-2):13-28, 2009.
  • Ballatori, N., Krance, S.M., Notenboom, S., Shi, S., Tieu, K., Hammond, C.L. Glutathione dysregulation and the etiology and progression of human diseases. Biol Chem. 390: 191-214, 2009.
  • Ballatori, N., Li, N., Fang, F., Boyer, J.L., Christian, W.V., Hammond, C.L. OST alpha-OST beta: a key membrane transporter of bile acids and conjugated steroids. Frontiers in Bioscience 14: 2829-44, 2009.
  • Bancos S, Bernard MP, Phipps PR. Ibuprofen and other widely used non-steroid anti-inflammatory drugs inhibit antibody production in human cells in vitro. Cellular Immunology 258(1):18-28, 2009
  • Bemis JC, Alejandro NF, Nazarenko DA, Brooks AI, Baggs RB, Gasiewicz TA. TCDD-induced alterations in gene expression profiles of the developing mouse paw do not influence morphological differentiation of this potential target tissue. Toxicol Sci 95(1):240-8, 2007.
  • Bernard, JJ, Seweryniak, KE, Koniski, AD, Spinelli, SL, Blumberg N, Francis, CW, Taubman, MB, Palis, J, Phipps, RP. Foxp3 regulates megakaryopoiesis and platelet function. Arteriosclerosis, Thrombosis, and Vascular Biology, In press: 2009.
  • Bernard MP, Bancos S, Sime PJ, Phipps PR. Targeting cyclooxygenase-2 in hematological malignancies: rationale and promise. Curr Pharm Des. 14(21):2051-60, 2008.
  • Caito S, Yang SR, Kode A, Edirisinghe I, Rajendrasozhan S, Phipps RP, Rahman I. Rosiglitazone and 15-deoxy-Delta12,14-prostaglandin J2, PPARgamma agonists, differentially regulate cigarette smoke-mediated pro-inflammatory cytokine release in monocytes/macrophages. Antioxid Redox Signal. 10(2):253-60, 2008.
  • Castaneda JA, Pearce DA. Identification of alpha-fetoprotein as an autoantigen in juvenile Batten
  • Castaneda JA, Lim MJ, Cooper JD, Pearce DA. Immune system irregularities in lysosomal storage disorders. Acta Neuropathol. 115(2):159-74, 2008.
  • Chen X, Xu L, Radcliffe P, Sun B, Tank AW. Activation of tyrosine hydroxylase mRNA translation by cAMP in midbrain dopaminergic neurons. Mol Pharmacol. 73(6):1816-28, 2008.
  • Collins, L. L.; Lew, B.J.; Lawrence, B. P. TCDD exposure disrupts mammary epithelial cell differentiation and function. Reprod Toxicol. 28(1) :11-7, 2009.
  • Collins LL, Williamson MA, Thompson BD, Dever DP, Gasiewicz TA, Opanashuk LA. 2,3,7,8-Tetracholorodibenzo-p-dioxin exposure disrupts granule neuron precursor maturation in the developing mouse cerebellum. Toxicol Sci. 103(1):125-36, 2008.
  • Cui, M., R. Aras, W.V. Christian, P.M. Rappold, M. Hatwar, J. Panza, V. Jackson-Lewis, J.A. Javitch, N. Ballatori, S. Przedborski, and K. Tieu. The organic cation transporter-3 is a pivotal modulator of neurodegeneration in the nigrostriatal dopaminergic pathway. Proc. Natl. Acad. Sci. U.S.A. 106(19):8043-8, 2009.
  • Deane R, Larue B, Sagare AP, Castellino FJ, Zhong Z, Zlokovic BV. Endothelial protein C receptor-assisted transport of activated protein C across the mouse blood-brain barrier. J Cereb Blood Flow Metab. 29(1):25-33, 2009.
  • de Boer WI, Yao H, Rahman I. Future therapeutic treatment of COPD: struggle between oxidants and cytokines. Int J Chron Obstruct Pulmon Dis. 2:205-228, 2007.
  • Edirisinghe I, Yang SR, Yao H, Rajendrasozhan S, Caito S, Adenuga D, Wong C, Rahman A, Phipps RP, Jin ZG, Rahman I. VEGFR2 inhibition augments cigarette smoke-induced oxidative stress and inflammatory responses leading to endothelial dysfunction, FASEB J, 22(7):2297-2310, 2008..
  • Farrer DG, Hueber S, Laiosa MD, Eckles KG, McCabe MJ Jr. Reduction of myeloid suppressor cell derived nitric oxide provides a mechanistic basis of lead enhancement of alloreactive CD4(+) T cell proliferation. Toxicol Appl Pharmacol. 229(2):135-45, 2008.
  • Garcia-Bates TM, Lehmann GM, Simpson-Haidaris PJ, Bernstein SH, Sime PJ, Phipps RP. Role of peroxisome proliferator-activated receptor gamma and its ligands in the treatment of hematological malignancies. PPAR Res. 2008:834612, 2008.
  • Gasiewicz TA, Henry EC, Collins LL. Expression and activity of aryl hydrocarbon receptors in development and cancer. Crit Rev Eukaryot Gene Expr. 18(4):279-321, 2008.
  • Gehen SC,Staversky RJ, Bambara RA, Keng PC, O’Reilly MA. hSMG-1 and ATM sequentially and independently regulate the G(1) checkpoint during oxidative stress. Oncogene. 27(29):4065-74, 2008.
  • Gehen SC, Vitiello PF, Bambara RA, Keng PC, O’eilly MA. Downregulation of PCNA potentiates p21-mediated growth inhibition in response to hyperoxia. Am J Physiol Lung Cell Mol Physiol. 292(3):L716-24, 2007.
  • Hammond CL, Marchan R, Krance SM, Ballatori N. Glutathione export during apoptosis requires functional multidrug resistance-associated proteins. J Biol Chem. 282(19):14337-47, 2007.
  • Holz, J.D., Tzong-jen Sheu, Hicham Drissi, Mitsuhiro Matsuzawa, Michael J. Zuscik, and J. Edward Puzas, Environmental Agents Affect Skeletal Growth and Development. Birth Defects Research (Part C) 81:41Ð50, 2007.
  • Kode A, Rajendrasozhan S, Caito S, Yang SR, Megson IL, Rahman I. Resveratrol induces glutathione synthesis by activation of Nrf2 and protects against cigarette smoke-mediated oxidative stress in human lung epithelial cells. American Journal of Physiology-Lung cellular and Molecular Physiology, 294(3):L478-488, 2008.
  • Laiosa MD, Eckles KG, Langdon M, Rosenspire AJ, McCabe MJ Jr. Exposure to inorganic mercury in vivo attenuates extrinsic apoptotic signaling in Staphylococcal aureus enterotoxin B stimulated T-cells. Toxicol Appl Pharmacol. 225(3):238-50, 2007.
  • Lakatos HF, Thatcher TH, Kottmann RM, Garcia TM, Phipps RP, Sime PJ. The Role of PPARs in Lung Fibrosis. PPAR Res. 2007:71323, 2007.
  • Lehmann DM, Galloway CA, MacElrevey C, Sowden MP, Wedekind JE, Smith HC. Functional characterization of APOBEC-1 complementation factor phosphorylation sites. Biochim Biophys Acta. 1773(3):408-18, 2007.
  • Lehmann GM, Feldon SE, Smith TJ, Phipps RP. Immune mechanisms in thyroid eye disease. Thyroid. 18(9):959-65, 2008.
  • Lehmann GM, Garcia-Bates TM, Smith TJ, Feldon SE, Phipps RP. Regulation of Lymphocyte Function by PPARgamma: Relevance to Thyroid Eye Disease-Related Inflammation. PPAR Res. 2008:895901, 2008.
  • Lehmann GM, McCabe MJ Jr. Arsenite slows S phase progression via inhibition of cdc25A dual specificity phosphatase gene transcription. Toxicol Sci. 99(1):70-8, 2007.
  • Lew, B.J.; Collins, L. L.; Lawrence, B. P. Activation of the aryl hydrocarbon receptor (AhR) during
    • different critical windows in pregnancy alters mammary epithelial cell proliferation and differentiation. Toxicol. Science, In press, 2009.
  • Li N, Cui Z, Fang F, Lee JY, Ballatori N. Heterodimerization, trafficking, and membrane topology of the two proteins that constitute the organic solute and steroid transporter, Ostalph and Ostbeta. Biochemical J. 407(3):363-72, 2007.
  • Luo Y, Xing F, Guiliano R, Federoff HJ. Identification of a novel nurr1-interacting protein. J Neurosci. 28(37):9277-86, 2008.
  • Luo Y, Henricksen LA, Giuliano RE, Prifti L, Callahan LM, Federoff HJ. VIP is a transcriptional target of Nurr1 in dopaminergic cells. Exp Neurol. 203(1):221-32, 2007.
  • Madejczyk, M.S., Aremu DA, Simmons-Willis TA, Clarkson TW, and N. Ballatori. Accelerated urinary excretion of methylmercury following administration of its antidote N-acetylcysteine requires Mrp2/Abcc2, the apical multidrug resistance-associated protein. J. Pharmacol. Exp. Ther. 322:378-384, 2007.
  • Madejczyk MS, Boyer JL, Ballatori N.ÊHepatic uptake and biliary excretion of manganese in the little skate, Leucoraja erinacea.ÊComp Biochem Physiol C Toxicol Pharmacol. 149(4):566-71, 2009.
  • Manickam R, Pena RN, Whitelaw CB. Mammary gland differentiation inversely correlates with GDF-8 expression. Mol Reprod Dev 75(12):1783-8, 2008
  • Marchan R, Hammond CL, Ballatori N. Multidrug resistance-associated protein 1 as a major mediator of basal and apoptotic glutathione release. Biochim Biophys Acta. 1778(10):2413-20, 2008.
  • McCabe MJ Jr, Laiosa MD, Li L, Menard SL, Mattingly RR, Rosenspire AJ. Low and nontoxic inorganic mercury burdens attenuate BCR-mediated signal transduction. Toxicol Sci. 2007 Oct;99(2):512-21, 2007.
  • Meja KK, Rajendrasozhan S (Joint first author), Adenuga D, Biswas SK, Sundar IK, Spooner G, Marwick JA, Chakravarty P, Fletcher D, Whittaker P, Megson IL, Kirkham PA, Rahman I. Curcumin restores corticosteroid function in monocytes exposed to oxidants by maintaining HDAC2. HYPERLINK "http://ajrcmb.atsjournals.org/" American Journal of Respiratory Cell and Molecular Biology, 39(3):312-323, 2008.
  • Mitsuhiro Matsuzawa, Tzong-Jen Sheu, Yi-jang Lee, Mo Chen, Tian-Fang Li,
  • Chia Taw Huang, Jonathan Holz, J. Edward Puzas Putative Signaling Action of Amelogenin Utilizes the Wnt/beta-Catenin Pathway. Journal of Periodontal Research 44(3):289-96, 2009.
  • Norman, J.P., S.W. Perry, K.A. Kasischke, D.J. Volsky, and H. A. Gelbard. HIV-1 trans activator of transcription protein elicits mitochondrial hyperpolarization and respiratory deficit, with dysregulation of complex IV and nicotinamide adenine dinucleotide homeostasis in cortical neurons. J. Immunol. 178(2):869-887, 2007.
  • O’Brien JJ, Baglole, CJ, Garcia-Bates TM, Blumberg N, Francis CW, Phipps RP. 15-deoxy-D12,14-PGJ2-induced heme oxygenase-1 regulates thrombopoiesis. J Thromb and Haemost. 7: 182, 2009.
  • O’rien JJ, Ray DM, Spinelli SL, Blumberg N, Taubman MB, Francis CW, Wittlin SD, Phipps RP.The platelet as a therapeutic target for treating vascular diseases and the role of eicosanoid and synthetic PPARgamma ligands. Prostaglandins Other Lipid Mediat. 82(1-4):68-76, 2007.
  • O’Brien JJ, Spinelli SL, Tober J, Blumberg N, Francis CW, Taubman MB, Palis J, Seweryniak KE, Gertz JM, Phipps RP. 15-deoxy-delta12,14-PGJ2 enhances platelet production from megakaryocytes. Blood 112:4051, 2008.
  • Rahman I and Adenuga D. Cigarette Smoke, Oxidative Stress and Corticosteroid Responsiveness. IN Adcock I, Chung KF. (Eds.) Overcoming Steroid Insensitivity in Respiratory Disease. London, John Wiley & Sons, Ltd, 2008.
  • Rajendrasozhan S, Yang SR, Kinnula VL, Rahman I. SIRT1, an anti-inflammatory and anti-aging protein, is decreased in lungs patients with COPD. American Journal of Respiratory and Critical Care Medicine, 177(8): 861-870, 2008.
  • Rajendrasozhan S, Yang SR, Edirisinghe I, Yao H, Adenuga D, Rahman I. Deacetylases and NF-kappaB in redox regulation of cigarette smoke-induced lung inflammation: epigenetics in pathogenesis of COPD. Antioxid Redox Signal. 10(4):799-811, 2008.
  • Ray DM, Spinelli SL, Pollock, SJ, Murante TI, O’Brien JJ, Blumberg N, Francis CW, Taubman, MB, Phipps RP. Peroxisome proliferator-activated receptor gamma and retinoid ex receptor transcription factors are released from activated human platelets and shed in microparticles. Thromb Haemost. 99:86-95, 2008.
  • Ryan EP, Bushnell TP, Friedman AE, Rahman I, Phipps RP. Cyclooxygenase-2 independent effects of cyclooxygenase-2 inhibitors on oxidative stress and intracellular glutathione content in normal and malignant human B-cells. Cancer Immunol Immunother. 57(3):347-58, 2008.
  • Ryan EP, Holz JD, Mulcahey M, Sheu TJ, Gasiewicz TA, Puzas JE. Environmental toxicants may modulate osteoblast differentiation by a mechanism involving the aryl hydrocarbon receptor. J Bone Miner Res. 22(10):1571-80, 2007.
  • Sagare A, Deane R, Bell RD, Johnson B, Hamm K, Pendu R, Marky A, Lenting PJ, Wu Z, Zarcone T, Goate A, Mayo K, Perlmutter D, Coma M, Zhong Z, Zlokovic BV. Clearance of amyloid-beta by circulating lipoprotein receptors. Nat Med. 13(9):1029-31, 2007.
  • Singh KP, Casado FL, Opanashuk LA, Gasiewicz TA. The aryl hydrocarbon receptor has a normal function in the regulation of hematopoietic and other stem/progenitor cell populations. Biochem. Pharmacol. 77(4):577-87, 2009.
  • Singh KP, Wyman A, Casado FL, Garrett R, Gasiewicz TA. Treatment of Mice with the Ah Receptor Agonist and Human Carcinogen Dioxin Results in Altered Numbers and Function of Hematopoietic Stem Cells. Carcinogenesis. 30(1):11-9, 2009.
  • Spinelli SL, O’rien JJ, Bancos S, Lehmann GM, Springer DL, Blumberg N, Francis CW, Taubman MB, Phipps RP. The PPAR-Platelet Connection: Modulators of Inflammation and Potential Cardiovascular Effects. PPAR Res.2008:328172, 2008.
  • Stahlhut, R.W., Welshons, W.V. & Swan, S.H. Bisphenol A Data in NHANES Suggest Longer Than Expected Half-Life, Substantial Non-Food Exposure, or Both. Environ Health Perspect. 117:784Ð789, 2009.
  • Sundar IK, Yao H, Rahman I. Methods in chromatin remodeling research. In: Dipak Das. (Ed) METHODS IN REDOX SIGNALING. Mary Ann Liebert. pp. 129-136, 2009.
  • Thatcher TH, Benson RP, Phipps RP, Sime PJ. High-dose but not low-dose mainstream cigarette smoke suppresses allergic airway inflammation by inhibiting T cell function. Am J Physiol Lung Cell Mol Physiol. 295(3):L412-21, 2008.
  • Thatcher TH, Maggirwar SB, Baglole CJ, Lakatos HF, Gasiewicz TA, Phipps RP, Sime PJ. Aryl hydrocarbon receptor-deficient mice develop heightened inflammatory responses to cigarette smoke and endotoxin associated with rapid loss of the nuclear factor-kappaB component RelB. Am J Pathol. 170(3):855-64, 2007.
  • Vezina CM, Allgeier SH, Moore RW, Lin TM, Bemis JC, Hardin HA, Gasiewicz TA, Peterson RE. Dioxin Causes Ventral Prostate Agenesis by Disrupting Dorsoventral Patterning in Developing Mouse Prostate. Toxicol Sci. Dec;106(2):488-96, 2008.
  • Vitiello PF, Staversky RJ, Keng PC, O’eilly MA. PUMA inactivation protects against oxidative stress through p21/Bcl-XL inhibition of bax death. Free Radic Biol Med. 44(3):367-74, 2008.
  • Vitiello PF, Wu YC, Staversky RJ, O’eilly MA. p21(Cip1) protects against oxidative stress by suppressing ER-dependent activation of mitochondrial death pathways. Free Radic Biol Med. 46(1):33-41, 2009.
  • Yang SR, Valvo S, Yao H, Kode A, Rajendrasozhan S, Edirisinghe I, Caito S, Adenuga D, Henry R, Fromm G, Maggirwar S, Li JD, Bulger M, Rahman I. IKK alpha causes chromatin modification on pro-inflammatory genes by cigarette smoke in mouse lung. Am J Respir Cell Mol Biol. 38(6):689-98, 2008.
  • Yang SR, Yao H, Rajendrasozhan S, Chung S, Edirisinghe I, Valvo S, Fromm G, McCabe Jr MJ, Edirisinghe I, Yang SR, Yao H, Rajendrasozhan S, Caito S, Adenuga D, Wong C, Rahman A, Phipps RP, Jin ZG, Rahman I. VEGFR-2 inhibition augments cigarette smoke-induced oxidative stress and inflammatory responses leading to endothelial dysfunction. FASEB J. 22(7):2297-310, 2008.
  • Yang SR, Yao H, Rajendrasozhan S, Chung S, Edirisinghe I, Valvo S, Fromm G, McCabe Jr MJ, Sime PJ, Phipps RP, Li JD, Bulger M, Rahman I. RelB is differentially regulated by IkappaB Kinase-alpha in B cells and mouse lung by cigarette smoke. HYPERLINK "http://ajrcmb.atsjournals.org/" American Journal of Respiratory Cell and Molecular Biology, 40(2):147-58, 2009.
  • Yao H, de Boer WI, Rahman I. Targeting Lung Inflammation: Novel Therapies for the Treatment of COPD. Curr Respir Med Rev. 4:57-68, 2008.
  • Yao H, Edirisinghe I, Yang SR, Rajendrasozhan S, Kode A, Caito S, Adenuga D, Rahman I. Genetic ablation of NADPH oxidase enhances susceptibility to cigarette smoke-induced lung inflammation and emphysema in mice. Am J Pathol. 172(5):1222-37, 2008.
  • Yao H, Edirisinghe I, Rajendrasozhan S, Yang SR, Caito S, Adenuga D, Rahman I. Cigarette smoke-mediated inflammatory and oxidative responses are strain-dependent in mice. Am J Physiol Lung Cell Mol Physiol. 294(6):L1174-86, 2008.
  • Yao H, Rahman I. An update on inflammation in COPD and lung cancer. Curr Opin Pharmacol. In press, 2009.
  • Yao H, Yang SR, Kode A, Rajendrasozhan S, Caito S, Adenuga D, Henry R, Edirisinghe I, Rahman I. Oxidative stress and redox regulation of lung inflammation in vitro and in vivo in mice. Biochemical Society Transactions 35 (Pt 5): 1151-5, 2007.
  • Yao H, Yang SR, Edirisinghe I, Rajendrasozhan S, Caito S, Adenuga D, O’eilly MA, Rahman I. Disruption of p21 attenuates lung inflammation induced by cigarette smoke, LPS, and fMLP in mice. Am J Respir Cell Mol Biol. 39(1):7-18, 2008.
  • Yin, Z., Henry E, Gasiewicz TG. (-)-Epigallocatachin Gallate is a Novel Hsp90 Inhibitor. Biochemistry 48: 336-345, 2009.
  • Zhang M, Zhou Q, Liang QQ, Li CG, Holz JD, Tang D, Sheu TJ, Li TF, Shi Q, Wang YJ. IGF-1 regulation of type II collagen and MMP-13 expression in rat endplate chondrocytes via distinct signaling pathways. Osteoarthritis Cartilage 17(1):100-6, 2009.
  • Zhang, Z. Q. Zhou, Q.-Q. Liang, C.-G. Li, J. D. Holz, D. Tang, T.-J. Sheu, T.-F. Li, Q. Shi and Y.-J. Wang, IGF-1 regulation of type II collagen and MMP-13 expression in rat endplate chondrocytes via distinct signaling pathways. Osteoarthritis and Cartilage 17:100-106, 2009.
  • Zhao CB, Coons SW, Cui M, Shi FD, Shi J. A new EAE model of brain demyelination induced by intracerebroventricular pertussis toxin. Biochem Biophys Res Commun. 370(1):16-21, 2008.
  • Zhan-Ying Tang, Bing Shu, Xue-Jun Cui, Chong-Jian Zhou, Qi Shi, Jonathan Holz, and Yong-Jun Wang, Changes of Cervical Dorsal Root Ganglia Induced by Compression Injury and Decompression Procedure: A Novel Rat Model of Cervical Radiculoneuropathy, J. Neurotrauma 26:1Ð7, 2009.
Revised August 20 2009 (vgl & gbi)